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Celiac Disease Antibody Screen

Celiac Disease Antibody Screen

This panel contains the following tests:

  • Deamidated gliadin IgA— This test may be positive in some people with CD who are negative for tTG, especially children less than 2 years old.
  • Tissue transglutaminase IgA— This is the most sensitive (>90%) and specific (>95%)1-3 blood test for celiac disease and is preferred for the detection of CD in people over 2 years of age.  Although “tissue” is in the name of this test it is measured in the blood.
  • Serum IgA level— This test is used to detect IgA deficiency. This deficiency occurs in about 2-3% of people with CD leading to false negative test results.

Celiac disease is a lifelong digestive disorder affecting both children and adults. Celiac disease is not a food allergy and is not the same as a wheat allergy; it is actually an autoimmune disease. If a person stops eating foods with gluten (for typically 3-6 months) before being tested, the results may be negative for celiac disease even if the disease is present. Fasting is not required for this test. Take all medications as prescribed.