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Lipase is used as a work-up for abdominal pain, nausea, and vomiting. Such findings characterize inflammation of the pancreas (pancreatitis). Pancreatitis is also associated with abnormalities in calcium metabolism. Usually acute pancreatitis leads to increased serum lipase within 24 hours. This test does not require fasting. Take all medications as prescribed. Do not take  supplements the morning of the test.