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Protein Electrophoresis, serum (SPE)

Protein Electrophoresis, serum (SPE)

The serum protein electrophoresis (SPE) test measures specific proteins in the blood.

Blood serum contains two major protein groups: albumin and globulin.  Using protein electrophoresis, these two groups can be separated into five smaller fractions:

  • Albumin
  • Alpha-1 globulin.
  • Alpha-2 globulin.
  • Beta globulin
  • Gamma globulin

The primary use of this test is in the evaluation of multiple myeloma; a cancer of white blood cells responsible for producing antibodies. Symptoms of multiple myeloma include bone pain, anemia, fatigue, unexplained fractures, and/or recurrent infections.