Protein Electrophoresis, serum (SPE)
The serum protein electrophoresis (SPE) test measures specific proteins in the blood.
Blood serum contains two major protein groups: albumin and globulin. Using protein electrophoresis, these two groups can be separated into five smaller fractions:
- Alpha-1 globulin.
- Alpha-2 globulin.
- Beta globulin
- Gamma globulin
The primary use of this test is in the evaluation of multiple myeloma; a cancer of white blood cells responsible for producing antibodies. Symptoms of multiple myeloma include bone pain, anemia, fatigue, unexplained fractures, and/or recurrent infections.